Pregnancy: Data are lacking on the use of apixaban in pregnant women. Animal studies have not demonstrated any evidence of fetotoxic effects; however, increased maternal bleeding was observed when apixaban was administered to pregnant animals at doses ranging from 1-19 times the human exposure at the maximum recommended dose.
Lactation: It is not known whether apixaban is excreted in breast milk. Apixaban is not recommended for use in breast-feeding women.